Monoclonal Anti-PCLO antibody produced in mouse

mouse

unconjugated

purified immunoglobulin

primary antibodies

6H9-B6, monoclonal

buffered aqueous glycerol solution

antigen predicted mol wt 550 kDa

human, rat

1 mg/mL

indirect ELISA: suitable
western blot: suitable

IgG2bκ

NP_001104266.1

Q9Y6V0

wet ice

−20℃

mouse ... Pclo(26875)

PCLO (presynaptic cytomatrix protein) gene codes for a protein called piccolo. The encoded protein is a component of the presynaptic active zone.

No cross-reactivity to Bassoon, band at ~550 kDa correspondng to the molecular weight of Piccolo.

Full length protein, Accession Number BC001304.1

PCLO (presynaptic cytomatrix protein) gene might be associated with the risk of major depression disorder and bipolar disorder. Mutation in PCLO gene results in pontocerebellar hypoplasia. PCLO serves as a biomarker type 2 diabetes. It controls presynaptic monoamine production. Piccolo plays an important role in synaptic transmission. It mediates the process of docking, vesicle priming and retrieval. Piccolo is involved in neurotransmission and functions at ribbon synapses. Loss of piccolo causes synapse degeneration due to the breakdown of many presynaptic proteins. It regulates ubiquitination, F-actin assembling and proteostasis which helps in maintaining synaptic integrity.

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Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

10 - Combustible liquids

WGK 1