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Monoclonal Anti-Phosphocan 小鼠抗
Monoclonal Anti-Phosphacan antibody produced in mouse
| 产品编号： | 3150169 |
| 规格： | ~2 mg/mL, clone 122.2, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-Phosphocan 小鼠抗
Monoclonal Anti-Phosphacan antibody produced in mouse
Anti-PTPRB
Anti-Receptor-type Protein-tyrosine phosphatase β
基本信息
| MDL number | MFCD09265428 |
| NACRES | NA.41 |
| General description【一般描述】 | Monoclonal Anti-Phosphacan (mouse IgM isotype) is derived from the hybridoma 122.2 produced by the fusion of mouse myeloma cells (P3X cells) and splenocytes from BALB/c mice immunized with rat brain proteoglycans. Chondroitin sulfate proteoglycans are neural cell adhesion molecules (NCAM) ligands present in the brain extracellular matrix (ECM). Phosphacan protein is expressed mainly in astrocytes and is a ligand for NCAM. Phosphacan is the soluble extracellular domain of the receptor-type transmembrane protein tyrosine phosphatase (RPTPb). |
| Immunogen【免疫原】 | rat brain proteoglycans. |
| Application【应用】 | Monoclonal Anti-Phosphacan antibody produced in mouse has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | Phosphacan levels elevates during late embryogenesis. It reaches a plateau two weeks postnatal before reaching stable. Receptor-type transmembrane protein tyrosine phosphatase (RPTPb) functions to promote primary tecal neurons neurite growth, neural migration and also induces cell adhesion. Both phosphacan and RPTPb can bind to NCAM and tenascin-C and −R. Phosphacan can oppose RPTPb by competing for its binding sites. Both in hippocampal and spinal cord neurons, phosphacan can affect neuronal adhesion and neurite outgrowth. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 122.2, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~180 kDa (higher band may be present) |
| species reactivity | rat |
| packaging【包装】 | antibody small pack of 25 μL |
| concentration【浓度】 | ~2 mg/mL |
| technique(s) | immunocytochemistry: suitable immunohistochemistry: suitable western blot: 0.2-0.4 μg/mL using total extract of rat brain |
| isotype【同位素/亚型】 | IgM |
| UniProt accession no.【UniProt登记号】 | Q62656 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | rat ... Ptprz1(25613) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
