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Anti-PP2A subunit B isoform PR55-α antibody, Mouse monoclonal
| 产品编号： | 3150527 |
| 规格： | clone 2G9, purified from hybridoma cell culture |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PP2A subunit B isoform PR55-α antibody, Mouse monoclonal
Anti-PR55A
Anti-Serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, alpha isoform
Anti-PR52A
Anti-B55α
Anti-PPP2R2A
Anti-Protein phosphatase 2, regulatory subunit B, alpha, B55A
Anti-Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform
产品性质
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| clone【克隆】 | 2G9, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 50-55 kDa |
| species reactivity | rat, mouse, human |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | immunohistochemistry: suitable indirect immunofluorescence: suitable western blot: 1-2 μg/mL using whole extracts of mouse 3T3, rat NRK or human HeLa cells |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | P63151 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PPP2R2A(5520) mouse ... Ppp2r2a(71978) rat ... Ppp2r2a(117104) |
基本信息
| General description【一般描述】 | Monoclonal Anti-PP2A subunit B isoform PR55- (mouse IgG1 isotype) is derived from the hybridoma 2G9 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of rat PP2A subunit B isoform PR55-. PP2A subunit B isoform PR55- (PPP2R2A) belongs to the phosphatase (PP)2A regulatory subunit B family. Protein phosphatase 2A is one of the major Ser/Thr phosphatases. PPP2R2A encodes an alpha isoform of the regulatory subunit B55 subfamily. This gene is mapped to human chromosome 8p21.2. |
| Specificity【特异性】 | Monoclonal Anti- PP2A subunit B isoform PR55-α binds to rat, human and mouse PP2A subunit B isoform PR55-α. The antibody may also react with rat PP2A-B55-δ, human PP2A-B55-β and weakly associates with rabbit PP2A-B55-γ. |
| Application【应用】 | Monoclonal Anti-PP2A subunit B isoform PR55-α antibody produced in mouse has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | PP2A is a serine/threonine phosphatase that downregulates the MAP kinase pathway and subsequently modulates mitogenic signaling. This phosphatase also mediates cellular invasion, localization of Sgo1 at centromeres, cell movement, Ras-1 activation, and chromosome segregation. PP2A protein complex consists of a dimeric core containing subunits A and C; which in turn associates with the regulatory subunit B. PP2A subunit B is involved in the degranulation of mast cells . Monoclonal Anti- PP2A subunit B isoform PR55-α binds to rat, human and mouse PP2A subunit B isoform PR55-α. The antibody may also react with rat PP2A-B55-δ, human PP2A-B55-β and weakly associates with rabbit PP2A-B55-γ. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
