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Anti-Prox1 antibody , Mouse monoclonal
| 产品编号： | 3150815 |
| 规格： | clone 4G10, purified from hybridoma cell culture |
| 包装规格： | 100 μL，200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Prox1 antibody , Mouse monoclonal
Anti-Homeobox prospero-like protein Prox1
Anti-Prospero homeobox 1
基本信息
| MDL number | MFCD09039204 |
| NACRES | NA.41 |
| General description【一般描述】 | Monoclonal Anti-Prox1 (mouse IgG2b isotype) is derived from the hybridoma 4G10 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant fusion protein of human Prox1. Prospero related homeobox gene 1 (Prox1) belongs to transcription factor subfamily and is homologous to Drosophila homeobox protein, prospero. |
| Immunogen【免疫原】 | recombinant fusion protein corresponding to amino acids 547-737 of human Prox1. |
| Application【应用】 | Anti-Prox1 antibody, Mouse monoclonal has been used in various immunochemical techniques. |
| Biochem/physiol Actions【生化/生理作用】 | Prospero related homeobox gene 1 (Prox1) is a key regulator for neuroblast fate determination and photoreceptor development. Prox1 regulates cell differentiation and organogenesis in lens, retina, lymphatic vessels, liver and pancreas. It was found to act as a tumor suppressor gene, because its deficiency or its mutated forms have been implicated in various human cancers. Knockdown of Prox1 by siRNA or by RNA mutations significantly accelerated the in vitro and in vivo growth of hepatocellular carcinoma (HCC) as well as esophageal cancer cells. Prox1 is hypermethylated and transcriptionally silenced in primary and metastatic breast cancer. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| clone【克隆】 | 4G10, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~84 kDa |
| species reactivity | human, lizard, rat, chicken |
| concentration【浓度】 | ~1.5 mg/mL |
| technique(s) | immunocytochemistry: suitable indirect ELISA: suitable indirect immunofluorescence: 2.5-5 μg/mL using paraformaldehyde fixed HepG2 cells western blot: suitable |
| isotype【同位素/亚型】 | IgG2b |
| UniProt accession no.【UniProt登记号】 | Q92786 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PROX1(5629) rat ... Prox1(305066) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
