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Anti-PSMA antibody, Mouse monoclonal

产品编号:3150858
规格:clone 107-1A4, purified from hybridoma cell culture
包装规格:25 μL,100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
315085825 μL1550
3150858100 μL5430
产品别名

Anti-PSMA antibody, Mouse monoclonal

PSMA Antibody-Monoclonal Anti-PSMA antibody produced in mouse

Monoclonal Anti-N-ACETYLATED ALPHA-LINKED ACIDIC DIPEPTIDASE 1

Monoclonal Anti-NAALAD

Monoclonal Anti-GCP2

Monoclonal Anti-GLUTAMATE CARBOXYPEPTIDASE II

Monoclonal Anti-PSM

Monoclonal Anti-FOLATE HYDROLASE 1

Monoclonal Anti-FOLH1

Monoclonal Anti-PROSTATE-SPECIFIC MEMBRANE ANTIGEN

Psma Antibody

基本信息
NACRES
NA.41
General description【一般描述】
Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), folate hydrolase 1 (FOLH1), is a 100kDa membrane glycoprotein, composed of 750 amino acids. PSMA gene with 19 exons and 18 introns is mapped to human chromosome 11p11–12. The encoded protein is detected in various type of tissues including kidney, prostate and brain. PSMA contains short cytoplasmic amino terminus, a single membrane-spanning domain and a large extracellular domain.
Monoclonal Anti-PSMA (mouse IgG1 isotype) is derived from the hybridoma 107-1A4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Prostate-specific membrane antigen (PSMA) is an integral, non-shed, type 2 transmembrane glycoprotein belonging to the M28 peptidase family.
Immunogen【免疫原】
prostate cancer LNCaP cells.
Application【应用】
Monoclonal Anti-PSMA antibody produced in mouse has been used in:
  • enzyme linked immuno sorbent assay (ELISA)
  • immunocytochemistry
  • immunoprecipitation
  • flow cytometry

Biochem/physiol Actions【生化/生理作用】
Prostate-specific membrane antigen (PSMA), expressed in the brain, catalyzes the hydrolysis of N-acetyl-aspartyl glutamate to produce free glutamate. Elevated expression of the protein is associated with the development of prostate tumor. Mutations in PSMA leads to hyperhomocysteinemia. PSMA functions as a potential biomarker of prostate adenocarcinoma.
Physical form【外形】
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
107-1A4, monoclonal
form【形式】
buffered aqueous solution
species reactivity
human
packaging【包装】
antibody small pack of 25 μL
concentration【浓度】
~1.0 mg/mL
technique(s)
flow cytometry: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: 5-10 μg/mL using methanol/acetone fixed LNCaP cells.
isotype【同位素/亚型】
IgG1
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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