您的位置：首页 > 产品中心 > Monoclonal Anti-PUMA antibody produced in mouse
Monoclonal Anti-PUMA antibody produced in mouse
| 产品编号： | 3151036 |
| 规格： | clone 2A8F6, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-PUMA antibody produced in mouse
Anti-Bcl-2 binding component 3
Anti-Bbc3
Anti-P53 upregulated modulator of apoptosis
基本信息
| MDL number | MFCD04040564 |
| NACRES | NA.41 |
| General description【一般描述】 | p53 upregulated modulator of apoptosis (PUMA), commonly known as BCL2 (B-cell lymphoma 2) binding component 3 (BBC3) encodes a mitochondrial protein. BBC3 has BH3 (Bcl-2 Homology 3) domain. PUMA is expressed in all the tissues at a very low levels. In human chromosome, the gene BBC3 is localized on 19q13.32. |
| Immunogen【免疫原】 | Mouse monoclonal PUMA antibody was raised against a recombinant protein corresponding to amino acids 76 – 170 of human PUMA-alpha. |
| Biochem/physiol Actions【生化/生理作用】 | p53 upregulated modulator of apoptosis (PUMA) is upregulated by p53, by binding to its promoter, inducing apoptosis in tumor cells. PUMA binds to Bcl2 and Bcl-xL (B-cell lymphoma-extra large) through BH3 domain and inhibits the antiapoptotic activity. PUMA releases p53 bound to Bcl-xL, and promotes p53 mediated apoptosis. PUMA causes apoptosis in colorectal cancer, ovarian cancer, and colon cancer. PUMA can be used as a directed gene therapy for in various forms of arthritis. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Supplied in PBS with 0.02% sodium azide. |
产品性质
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 2A8F6, monoclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | rat, human |
| technique(s) | indirect ELISA: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | Q9BXH1 |
| UniProt accession no.【UniProt登记号】 | Q9BXH1 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... BBC3(27113) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
