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Monoclonal Anti-S1P2, C-Terminal antibody produced in mouse
| 产品编号： | 3151829 |
| 规格： | clone AS65, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 0.1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-S1P2, C-Terminal antibody produced in mouse
Anti-Endothelial Cell Differentiation Gene 5, C-Terminal
Anti-EDG-5
基本信息
| MDL number | MFCD02686109 |
| NACRES | NA.41 |
| Immunogen【免疫原】 | human EDG-5/S1P2 unique C-terminal peptide. |
| Application【应用】 | Monoclonal Anti-S1P2, C-Terminal antibody produced in mouse is suitable for western blotting at a working dilution of 1:1000 (1μg/mL) using human T lymphoblasts, ovarian tumor cells, epithelial cells, estrogen receptor positive breast carcinoma cells, human spleen and rat spleen or lung. |
| Biochem/physiol Actions【生化/生理作用】 | Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodes a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P. |
| Preparation Note【制备说明】 | Purified from in vitro cell culture supernatants using protein A. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | AS65, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~45 kDa |
| species reactivity | human, rat |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG |
| UniProt accession no.【UniProt登记号】 | O95136 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... S1PR2(9294) rat ... S1pr2(29415) |
产品说明
| Target description【目标描述】 | EDG-5/S1P2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-5/S1P2 is sphingosine 1-phosphate, and is expressed in cardiovascular, central nervous system, gonadal, placental and leukocyte-containing tissue. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
