Monoclonal Anti-S1P₄, C-Terminal antibody produced in mouse

MFCD03454969

NA.41

Specifically detects human recombinant and native EDG-6/S1P₄ protein (approximately 45 kDa).

synthetic peptide derived from the C-terminal region of the EDG-6/S1P₄ protein.

Anti-S1P₄, C-Terminal antibody produced in rabbit is suitable for western blotting and flow cytometry at a working antibody concentration of 5-10μg/mL using RH7777 rat hepatoma cells transfected with EDG-6 protein.

Sphingosine-1-phosphate receptor 4 (S1PR4, EDG-6) is a human gene, which encodes a G protein-coupled receptor and is identified as an orphan G-protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P). EDG-6 is a member of the endothelial differentiation gene (EDG) G protein-coupled receptor family. It is expressed in lymphoid, hematopoietic tissue and in the lung. EDG-6 acts as a high affinity receptor for SPP that couples to a G(i/o) protein leading to the activation of growth-related signaling pathways. It is one of the S1P or lysosphingolipid receptors that couples to phospholipase C-Ca²⁺ system through pertussis toxin-sensitive G-proteins.

To detect native EDG-6/S1P₄ in cells and tissues, use higher antibody concentrations.

200

mouse

unconjugated

purified immunoglobulin

primary antibodies

1, monoclonal

buffered aqueous solution

human

~1 mg/mL

flow cytometry: suitable
western blot: suitable

IgG1

O95977

wet ice

−20℃

human ... S1PR4(8698)

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