2,4-二氯-5-氟嘧啶

C₄HCl₂FN₂

166.97

MFCD00233551

24883938

NA.22

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:

• 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
• A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
• 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
• 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
• 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
• 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

100

97%

37-41 ℃ (lit.)

Fc1cnc(Cl)nc1Cl

1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H

WHPFEQUEHBULBW-UHFFFAOYSA-N

1 g in glass bottle

GHS05,GHS07

Danger

H302 - H314

P260 - P280 - P301 + P312 + P330 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338

Acute Tox. 4 Oral - Skin Corr. 1B

8A - Combustible, corrosive hazardous materials

WGK 3

222.8 °F - closed cup

106 ℃ - closed cup

Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges