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Anti-SND1 antibody, Mouse monoclonal
产品编号: | 3152473 |
规格: | clone SND1-3, purified from hybridoma cell culture |
包装规格: | 200 μL |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-SND1 antibody, Mouse monoclonal
Monoclonal Anti-TDRD11
Monoclonal Anti-staphylococcal nuclease and tudor domain containing 1, p100
Monoclonal Anti-SND1 antibody produced in mouse
基本信息
NACRES | NA.41 |
General description【一般描述】 | Monoclonal Anti-SND1 (mouse IgG1 isotype) is derived from the hybridoma SND1-3 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. The Staphylococcal nuclease and tudor domain containing 1 (SND1) protein is highly conserved from yeast to human. It contains five repeated staphylococcal nuclease-like domains and a tudor-like domain, probably required for its interaction with nucleic acids and proteins, respectively. The SND1 protein is a constituent of the RNA-induced silencing complex (RISC). The SND1 gene is mapped to the human chromosome location 7q31.3. |
Specificity【特异性】 | Monoclonal Anti-SND1 recognizes human, mouse, rat, hamster and bovine SND1. |
Immunogen【免疫原】 | Synthetic peptide corresponding to an internal region of human SND1, conjugated to KLH. The corresponding sequence differs by a single amino acid in mouse and rat SND1. |
Application【应用】 | Monoclonal Anti-SND1 antibody produced in mouse may be used in:
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Biochem/physiol Actions【生化/生理作用】 | The Staphylococcal nuclease and tudor domain containing 1 (SND1) protein is involved in the regulation of transcription. It also modulates the RNA interference (RNAi) function, RNA splicing, editing and stability. The SND1 protein promotes the degradation of hyper-edited inosine containing miRNA precursors. It modulates miRNA processing and expression through RNA editing by adenosine deaminase acting on RNA (ADAR). SND1 is up-regulated in human colon cancer, breast cancer and cancer cell lines. This protein promotes nucleic acid interaction along with protein-protein interactions. It also interacts with transcription factors as a transcriptional co-activator of Epstein-Barr virus nuclear antigen 2 (EBNA2) and signal transducer and activator of transcription (STAT5 and STAT6). |
Physical form【外形】 | 0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。 |
产品性质
Quality Level【质量水平】 | 200 |
biological source【生物来源】 | mouse |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | purified from hybridoma cell culture |
antibody product type | primary antibodies |
clone【克隆】 | SND1-3, monoclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | antigen ~102 kDa |
species reactivity | mouse, human, rat |
concentration【浓度】 | ~1.0 mg/mL |
technique(s) | western blot: 1-2 μg/mL using whole extracts of human HeLa or HEK-293T cells. |
isotype【同位素/亚型】 | IgG1 |
UniProt accession no.【UniProt登记号】 | Q7KZF4 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... SND1(27044) mouse ... Snd1(56463) rat ... Snd1(64635) |
产品说明
Storage and Stability【储存及稳定性】 | For continuous use, store at 2-8℃ for up to one month. For extended storage, freeze at -20oC in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |