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Monoclonal Anti-SSH3 antibody produced in mouse
| 产品编号： | 3152706 |
| 规格： | clone 6F9, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-SSH3 antibody produced in mouse
Anti-FLJ10928
Anti-SSH3
Anti-slingshot homolog 3 (Drosophila)
Anti-FLJ20515
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 6F9, monoclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable immunoprecipitation (IP): suitable indirect ELISA: suitable indirect immunofluorescence: suitable western blot: 1-5 μg/mL |
| isotype【同位素/亚型】 | IgG2aκ |
| GenBank® accession no. | NM_017857 |
| UniProt accession no.【UniProt登记号】 | Q8TE77 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... SSH3(54961) |
基本信息
| General description【一般描述】 | The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM |
| Immunogen【免疫原】 | SSH3 (NP_060327, 293 a.a. ~ 391 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence SKEIRQALELRLGLPLQQYRDFIDNQMLLLVAQRDRASRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPH |
| Biochem/physiol Actions【生化/生理作用】 | SSH3 (Slingshot protein phosphatase 3) is involved in the actin filament assembly. During actin reorganization, LIM-kinase 1 (LIMK1) restricts the activity of ADF (actin-depolymerizing factor)/cofilin, which is a stimulus-responsive mediator of actin dynamics. SSH3 blocks the LIMK1 functions and reactivates ADF/cofilin in vivo by the dephosphorylating it. In addition, it is also involved in several cellular and developmental activities. |
| Physical form【外形】 | Solution in phosphate buffered saline, pH 7.4 |
| Legal Information【法律信息】 | GenBank is a registered trademark of United States Department of Health and Human Services |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
