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Monoclonal Anti-TBP 小鼠抗
Monoclonal Anti-TBP antibody produced in mouse
产品编号: | 3153254 |
规格: | ~2.0 mg/mL, clone 58C9, purified immunoglobulin, buffered aqueous solution |
包装规格: | 200 μL |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Monoclonal Anti-TBP 小鼠抗
Monoclonal Anti-TBP antibody produced in mouse
Anti-TATA box binding protein
Anti-SCA17
Anti-GTF2D
Anti-TFIID
Anti-GTF2DI
基本信息
MDL number | MFCD01322691 |
NACRES | NA.41 |
General description【一般描述】 | TBP (TATA-binding protein) is encoded by the gene mapped to human chromosome 6q27. The encoded protein is a key constituent of RNA polymerase II transcription apparatus in eukaryotic cells. Monoclonal Anti-TBP (mouse IgG2b isotype) is derived from the hybridoma 58C9 produced by the fusion of mouse myeloma cells and splenocytes from Swiss Webster mice immunized with Drosophila TFIID complex. Transcription factor IID (TFIID) complex contains the TATA-binding protein (TBP) and over a dozen of TBP-associated factors (TAFs). |
Immunogen【免疫原】 | Drosophila TFIID complex. |
Application【应用】 | Monoclonal Anti-TBP antibody produced in mouse has been used in:
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Biochem/physiol Actions【生化/生理作用】 | TBP facilitates promoter recognition with the help of the sequence-specific binding of the TATA element found in many promoters. The TBP (TATA-binding protein) gene encodes a subunit of TFIIIB (transcription factor IIIB) complex and recognizes the TATA box in the DNA. Thus, it plays an important role in RNA polymerase II transcription machinery. TBP is known to induce stress granule formation in hepatitis B viral infection. Mutation in the gene is associated with the development of spinocerebellar ataxia 17 (SCA17). |
Physical form【外形】 | 0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。 |
产品性质
Quality Level【质量水平】 | 200 |
biological source【生物来源】 | mouse |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | 58C9, monoclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | antigen ~42 kDa |
species reactivity | Drosophila melanogaster, yeast, Sf9 cell line, human |
concentration【浓度】 | ~2.0 mg/mL |
technique(s) | immunoprecipitation (IP) western blot |
isotype【同位素/亚型】 | IgG2b |
UniProt accession no.【UniProt登记号】 | P20226 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | Drosophila melanogaster ... Tbp(37476) human ... TBP(6908) |
产品说明
Target description【目标描述】 | TBP encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of tr |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |