Monoclonal Anti-TIS7 antibody produced in mouse

MFCD08705605

NA.41

The tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7), also known as interferon related developmental regulator 1 (FRD1), is mapped to human chromosome 7q31.1. The gene with 13 exons, spans about 52kb of genomic DNA. The encoded protein consists of 451 amino acids and is expressed in mature neutrophils.

synthetic peptide corresponding to amino acids 30-47 of mouse Tis7, conjugated to KLH.

Monoclonal Anti-TIS7 antibody produced in mouse has been used in western blot analysis.

Tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7)/interferon related developmental regulator 1(FRD1) is implicated in regulation of the proliferation and differentiation pathways induced by nerve growth factor (NGF). The encoded protein also plays a vital role in myocyte differentiation, and it modulates the nuclear factor-κB (NF-κB) pathway by influencing the activity of histone deacetylases and forming complexes with the p65 subunit of NFκB. Genetic variations in the gene is associated with the development of various diseases such as sensory/motor neuropathy with ataxia (SMNA), cystic fibrosis, lung disease and myelodysplastic syndrome (MDS). TIS7 is also implicated in regulation of airway inflammation.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

200

mouse

unconjugated

purified immunoglobulin

primary antibodies

IRT537, monoclonal

buffered aqueous solution

antigen ~50 kDa

human, mouse

~2 mg/mL

immunocytochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.25-0.5 using extracts of COS7 cells transfected with mouse Tis7

IgG2a

O00458

dry ice

−20℃

human ... IFRD1(3475)
mouse ... Ifrd1(15982)
rat ... Ifrd1(29596)

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