Monoclonal Anti-TTN antibody produced in mouse

100

mouse

unconjugated

purified immunoglobulin

primary antibodies

2B3, monoclonal

buffered aqueous solution

human

immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

IgG1κ

BC058824

Q8WZ42

dry ice

−20℃

human ... TTN(7273)

TTN (Titin) is the giant muscle protein consisting of a catalytic serine kinase domain. The gene encoding this protein is localized on human chromosome 2q31.2.

TTN (AAH58824, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MTTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRL

Titin (TTN) is an elastic protein that maintains cardiac muscle elasticity. S-glutathionylation of cryptic cysteines inhibits protein folding as well as disrupts mechanical stability that further increases titin elasticity through posttranslational modifications. TTN controls the temporal and spatial organizations of the striated muscle. During myofibrillogenesis, it phosphorylates the muscle protein telethonin for differentiating myocytes.

Solution in phosphate buffered saline, pH 7.4

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Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)