Monoclonal Anti-TUBB3-FITC antibody produced in mouse

NA.41

Tubulin β 3 class III (TUBB3) also known as β-tubulin III, is encoded by the gene mapped to human chromosome 16q24.3. TUBB3 protein expression is restricted to neurons.
The antibody TU-20 recognizes C-terminal peptide sequence ESESQGPK (aa 441-448) of neuron-specific human betaIII-tubulin.

Peptide (C) 441-448 coupled to maleimide-activated keyhole limpet hemocyanin via cysteine added to the N-terminus of the neuron-specific peptide

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1:40. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Monoclonal Anti-TUBB3-FITC antibody produced in mouse has been used in immunoassays.

Tubulin β 3 class III (TUBB3) plays a vital role in nervous system development and axon guidance. Mutation of the gene encoding protein leads to the ocular motility disorder, congenital fibrosis of the extraocular muscle type 3 (CFEOM3), and various neurological syndromes. Altered expression of the protein affects microtubule dynamics and microtubule-kinesin interactions. Increased expression of TUBB3 is observed in tumor tissues. Decreased expression of TUBB3 can be considered as an important marker for poor prognosis of cutaneous malignant melanoma. TUBB3 is implicated in the suppression of invasive growth of tumor tissue. Thus, it is considered to be a potential target for development of antitumor drugs.

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Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

mouse

FITC conjugate

purified immunoglobulin

primary antibodies

TU-20, monoclonal

buffered aqueous solution

wide range

1 mg/mL

flow cytometry: suitable

IgG1

NM_001197181.1

wet ice

2-8℃

human ... TUBB3(10381)

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