Monoclonal Anti-USP25 antibody produced in mouse

NA.41

Monoclonal Anti-USP25 (mouse IgG2a isotype) is derived from the hybridoma U25.7 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human USP25. USP25 (ubiquitin-specific protease 25) is a member of the ubiquitin processing proteases (UBP) family. It is located on the gene-poor region of 21q11.2 human chromosome.

Monoclonal Anti-USP25 antibody has been used in:

• enzyme linked immunosorbent assay (ELISA)
• immunoblotting
• immunocytochemistry

USP25 (ubiquitin-specific protease 25) is a target for sumoylation. It takes place within the two ubiquitin interaction motifs (UIM) of USP25 that are required for efficient hydrolysis of Ub (ubiquitin), and thus impairs USP25 activity as a result of reduced affinity to Ub chains. Overexpression of USP25 has been observed in Down syndrome fetal brain.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

200

mouse

unconjugated

purified immunoglobulin

primary antibodies

U25.7, monoclonal

buffered aqueous solution

antigen ~126 kDa

human, rat, mouse

~1.0 mg/mL

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 1-2 μg/mL using total extract of HEK-293T cells expressing USP25.

IgG2a

Q9UHP3

dry ice

−20℃

human ... USP25(29761)
mouse ... Usp25(30940)
rat ... Usp25(304150)

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