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Monoclonal Anti-WDR62 antibody produced in mouse
| 产品编号： | 3154475 |
| 规格： | ~1.0 mg/mL, clone 3G8, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-WDR62 antibody produced in mouse
Anti-C19orf14
Anti-WD repeat domain 62
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 3G8, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~170 kDa |
| species reactivity | human |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: 0.5-1 μg/mL using HEK-293T cells over expressing human WDR62 western blot: 0.5-1 μg/mL using HEK-293T cells over expressing human WDR62 |
| isotype【同位素/亚型】 | IgG2a |
| UniProt accession no.【UniProt登记号】 | O43379 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... WDR62(284403) |
基本信息
| General description【一般描述】 | Monoclonal Anti-WDR62 (mouse IgG2a isotype) is derived from the hybridoma 3G8 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a fusion protein encoding a fragment of human WDR62. WD repeat 62 is a member of WD-repeats and contains 15 WD repeats. WD-repeats consists of minimally conserved domains of 40-60 amino acids, which are initiated by glycine-histidine (GH) dipeptide 11 to 24 residues from the N-terminus and ends with tryptophan-aspartic acid (WD) dipeptide at the C terminus. |
| Application【应用】 | Monoclonal Anti-WDR62 antibody produced in mouse has been used in immunoblotting and immunofluorescence. |
| Biochem/physiol Actions【生化/生理作用】 | WD repeat 62 (WDR62) is identified in a phosphoproteome analysis as a protein associated with the mitotic spindle. It physically interacts with RNA-binding protein (RALY), TATA-binding protein (TBP), C1 or f103, mitogen-activated protein kinase (MAPK9) and itself. WDR62 potentiates c-Jun N-terminal kinase (JNK) activity. Mutations in this gene are linked to microcephaly and cortical malformations. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品说明
| Target description【目标描述】 | WDR62 contains 15 WD repeats and has been identified in aphosphoproteome analysis as a protein associated with the mitotic spindle. WD40 proteins are implicated in many essential biologicalfunctions including adaptor/regulatory modules in signaltran |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
