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Mps1-IN-3
产品别名
Mps1-IN-3
1-(4-(6-(2-(Isopropylsulfonyl)phenylamino)-9H-purin-2-ylamino)-3-methoxyphenyl)piperidin-4-ol
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H31N7O4S |
| Molecular weight | 537.63 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825614 |
| NACRES | NA.77 |
| General description【一般描述】 | Monopolar spindle 1 (Mps1) protein contains a TPR (tetratricopeptide repeat) motif at its N-terminal and a C-terminal kinase domain. |
| Application【应用】 | Mps1-IN-3 has been used in 2D-proliferation and 3D-organotypic culture outgrowth assays. |
| Biochem/physiol Actions【生化/生理作用】 | Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1, also known as TTK), a Dual-specificity kinase required for spindle pole body duplication and spindle checkpoint function. Mps1-IN-3 inhibited Mps1 kinase activity with an IC50 value of 50 nM inhibited the proliferation of U251 glioblastoma cells as determined by cell counting with an IC50 value of approximately 5 μM, and sensitized glioblastoma cells to vincristine in orthotopic mouse models. Mps1 mediates phosphorylation of kinetochore scaffold 1. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | light yellow to dark yellow |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC1CCN(C2=CC=C(NC3=NC(NC=N4)=C4C(NC5=C(S(=O)(C(C)C)=O)C=CC=C5)=N3)C(OC)=C2)CC1 |
| InChI | 1S/C26H31N7O4S/c1-16(2)38(35,36)22-7-5-4-6-20(22)29-25-23-24(28-15-27-23)31-26(32-25)30-19-9-8-17(14-21(19)37-3)33-12-10-18(34)11-13-33/h4-9,14-16,18,34H,10-13H2,1-3H3,(H3,27,28,29,30,31,32) |
| InChI key | OFRMASLPWOMYHN-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
