MRS 1754 hydrate

C₂₆H₂₆N₆O₄ · xH₂O

486.52 (anhydrous basis)

MFCD11046004

24278793

NA.77

MRS 1754 hydrate has been used as an adenosine receptor A2B (RA2B) antagonist:

• to study its effects on endothelial nitric oxide synthase (eNOS) phosphorylation induced by short-term acetate stimulation in human umbilical vein endothelial cells (HUVECs)
• blastema formation in zebrafish
• to serve as a positive control in the anti-sickling assay and to study the role of RA2B in the same

MRS 1754 hydrate is a p-cyanoanilide xanthine derivative. It might act as a potential anti-asthmatic drug.
MRS 1754 hydrate is a potent A_2B adenosine receptor antagonist.

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Manufactured and sold under license from Adenosine Therapeutics LLC.

100

≥98% (HPLC)

solid

off-white

DMSO: soluble >10 mg/mL

room temp

O.CCCN1C(=O)N(CCC)c2[nH]c(nc2C1=O)-c3ccc(OCC(=O)Nc4ccc(cc4)C#N)cc3

1S/C26H26N6O4.H2O/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19;/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30);1H2

ZACJDWOPQROWIK-UHFFFAOYSA-N

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316)

5, 25 mg in glass bottle

11 - Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)