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N-Acetyl-Glu-Ser-Met-Asp-al
产品别名
191338-87-1
N-Acetyl-Glu-Ser-Met-Asp-al
Ac-ESMD-CHO
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H30N4O10S |
| Molecular weight | 506.53 |
| MDL number | MFCD01318859 |
| PubChem Substance ID【PubChem化学物质编号】 | 329770361 |
| NACRES | NA.77 |
| General description【一般描述】 | N-Acetyl-Glu-Ser-Met-Asp-aldehyde (Ac-ESMD-CHO) is a tetrapeptide analog that act to inhibit the activity of caspase-3 and caspase-7 proteins, which are involved in apoptosis. Ac-ESMD-CHO has been shown to block formation of the caspase-3 p17 and p12 subunits, induce accumulation of the p20 precursor peptide, inhibit 25-hydroxycholesterol-induced apoptosis in rat Sertoli cells and also to bind caspase-7. |
| Biochem/physiol Actions【生化/生理作用】 | In the caspase-3 precursor, procaspase-3, the ESMD amino acid sequence has been identified as a cleavage site for producing the p17 and p12 subunits of mature caspase 3; Ac-ESMD-CHO has been shown to inhibit the protease that cleaves procaspase-3 at this site. Ac-ESMD-CHO binds caspase-7 and inhibits with a Ki of approximately 1300 nM, which makes it a weaker inhibitor than other inhibitor tetrapeptide analogs. |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥90% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white |
| solubility【溶解性】 | H2O: 1 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C=O |
| InChI | 1S/C19H30N4O10S/c1-10(26)20-12(3-4-15(27)28)18(32)23-14(9-25)19(33)22-13(5-6-34-2)17(31)21-11(8-24)7-16(29)30/h8,11-14,25H,3-7,9H2,1-2H3,(H,20,26)(H,21,31)(H,22,33)(H,23,32)(H,27,28)(H,29,30)/t11-,12-,13-,14-/m0/s1 |
| InChI key | TVTYMGFOGZRIHG-XUXIUFHCSA-N |
| packaging【包装】 | 1 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
