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N2-Ethyl-2′-deoxyguanosine
| 产品编号： | 3171796 |
| 规格： | ≥98% (HPLC), solid |
| CAS NO： | 101803-03-6 |
| 包装规格： | 5 MG，25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
101803-03-6
N2-Ethyl-2′-deoxyguanosine
N2-Et-dG
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H17N5O4 |
| Molecular weight | 295.29 |
| MDL number | MFCD01631004 |
| PubChem Substance ID【PubChem化学物质编号】 | 329818605 |
| NACRES | NA.77 |
| General description【一般描述】 | N2-Et-dG, an adduct between DNA and the first metabolite of ethanol (acetaldehyde), strongly blocks transcription by RNA polymerases (RNAPs), including mammalian RNAPII and yeast RNAPII, E. coli RNAP, as well as T7 RNAP. All three of the multisubunit RNAPs incorporate a single rNTP residue opposite the N2-Et-dG lesion. The mammalian RNAPII exclusively incorporates cytidine monophosphate (CMP) opposite the N2-Et-dG lesion. The accessory transcription factor TFIIS does not usually act as a lesion bypass factor; instead, it stimulates the polymerase to remove the CMP incorporated opposite the lesion by mammalian RNAPII. N2-Et-dG reduces CTP incorporation by ~1500 fold. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | H2O: >5 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CCNC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1 |
| InChI | 1S/C12H17N5O4/c1-2-13-12-15-10-9(11(20)16-12)14-5-17(10)8-3-6(19)7(4-18)21-8/h5-8,18-19H,2-4H2,1H3,(H2,13,15,16,20)/t6-,7+,8+/m0/s1 |
| InChI key | VOKQFDULHQUWAV-XLPZGREQSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H300 + H310 + H330 - H351 - H373 |
| Precautionary Statements | P201 - P202 - P260 - P280 - P302 + P352 + P310 - P304 + P340 + P310 |
| Hazard Classifications【危险分类】 | Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Carc. 2 - STOT RE 2 |
| Storage Class Code【储存分类代码】 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
