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NCTT-956
产品别名
438575-88-3
NCTT-956
N-[(8-Hydroxy-5-nitro-7-quinolinyl)-2-thienylmethyl]-propanamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H15N3O4S |
| Molecular weight | 357.38 |
| MDL number | MFCD02228855 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825448 |
| Biochem/physiol Actions【生化/生理作用】 | NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity, with an IC50 of 800 nM, no activity against 5-LO and greater than 25-fold selectivity over 15-LO. Specific inhibition of 12-LO by NCTT-956 in platelets blocks PKC activation, aggregation, granule secretion and αIIbB3 activation. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (NMR) |
| form【形式】 | powder |
| color【颜色】 | light orange to dark orange |
| solubility【溶解性】 | DMSO: 5 mg/mL (clear solution) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CCC(=O)NC(c1cccs1)c2cc([N+]([O-])=O)c3cccnc3c2O |
| InChI | 1S/C17H15N3O4S/c1-2-14(21)19-15(13-6-4-8-25-13)11-9-12(20(23)24)10-5-3-7-18-16(10)17(11)22/h3-9,15,22H,2H2,1H3,(H,19,21) |
| InChI key | DEXNORPUTBBNSC-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H319 |
| Precautionary Statements | P301 + P312 + P330 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Eye Irrit. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
