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NGB 2904 hydrochloride
产品别名
189061-11-8
NGB 2904 hydrochloride
N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C28H29Cl2N3O·HCl |
| Molecular weight | 530.92 |
| MDL number | MFCD09971107 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825130 |
| NACRES | NA.77 |
| Application【应用】 | NGB 2904 hydrochloride may be used in cell signaling studies. |
| Biochem/physiol Actions【生化/生理作用】 | Inhibition of dopamine D3 receptor function by NGB 2904 increases spontaneous locomotor activity in rodents. NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine. |
| Features and Benefits【特点和优势】 | This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to tan |
| solubility【溶解性】 | DMSO: ≥25 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl.Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl |
| InChI | 1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H |
| InChI key | PFIWYJNBKGCVFM-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
