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NQ301
产品别名
130089-98-4
NQ301
2-Chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone
2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione
NQ 301
Compound 211
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C23H19N3O · HBr |
| Molecular weight | 434.33 |
| MDL number | MFCD00559986 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825795 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | , faint red to dark red |
| solubility【溶解性】 | DMSO: 10 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O |
| InChI | 1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3 |
| InChI key | LSQZKIQSQHZVQS-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07,GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 - H400 |
| Precautionary Statements | P273 - P280 - P304 + P340 + P312 - P305 + P351 + P338 - P337 + P313 - P391 |
| Hazard Classifications【危险分类】 | Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
