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Osteoprotegerin/Fc Chimera from mouse

产品编号:3177796
规格:>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3177796100 μG6320
产品别名

Osteoprotegerin/Fc Chimera from mouse

OPG

OCIF

结构式
基本信息
MDL number
MFCD01867131
PubChem Substance ID【PubChem化学物质编号】
24898055
NACRES
NA.32
General description【一般描述】
Osteoprotegerin (OPG) is a member of the TNFR (tumor necrosis factor receptor) superfamily that can act as a decoy receptor for RANKL (receptor activator of nuclear factor κ-B ligand) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand). The primary structure of OPG protein consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney and liver. It is secreted both as a monomeric and a dimeric protein.
Biochem/physiol Actions【生化/生理作用】
OPG is a soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs. It regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG.
Binding of soluble osteoprotegerin (OPG) to sRANKL (soluble receptor activator of nuclear factor κ-B ligand) inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Changes in the level of serum OPG are associated with atherosclerosis and cardiovascular disorders. It might also be associated with malignancy and plays a regulatory role in multiple myeloma, prostate, breast, bladder and gastric carcinoma. OPG plays a vital role in bone metabolism and is involved in inhibition of ovariectomy-associated bone loss in rats.
Physical form【外形】
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Analysis Note【分析说明】
The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 50 ng/ml recombinant human TRAIL.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
recombinant【重组】
expressed in NSO cells
Assay【测定】
>95% (SDS-PAGE)
form【形式】
lyophilized powder
potency【效能】
25-50 ng/mL ED50
mol wt【分子量】
100 kDa by SDS-PAGE (reducing)
calculated mol wt 70.9 kDa
packaging【包装】
pkg of 100 μg
impurities【杂质】
endotoxin, tested
UniProt accession no.【UniProt登记号】
O08712
storage temp.【储存温度】
−20℃
SMILES string
CCCCCCCCCCC#CCCCCCC(O)=O
InChI
1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-10,13-17H2,1H3,(H,19,20)
InChI key
XXUPLYBCNPLTIW-UHFFFAOYSA-N
Gene Information
mouse ... Tnfrsf11b(18383)
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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