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Osteoprotegerin/Fc Chimera from mouse
产品编号: | 3177796 |
规格: | >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Osteoprotegerin/Fc Chimera from mouse
OPG
OCIF
结构式
基本信息
MDL number | MFCD01867131 |
PubChem Substance ID【PubChem化学物质编号】 | 24898055 |
NACRES | NA.32 |
General description【一般描述】 | Osteoprotegerin (OPG) is a member of the TNFR (tumor necrosis factor receptor) superfamily that can act as a decoy receptor for RANKL (receptor activator of nuclear factor κ-B ligand) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand). The primary structure of OPG protein consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney and liver. It is secreted both as a monomeric and a dimeric protein. |
Biochem/physiol Actions【生化/生理作用】 | OPG is a soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs. It regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG. Binding of soluble osteoprotegerin (OPG) to sRANKL (soluble receptor activator of nuclear factor κ-B ligand) inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Changes in the level of serum OPG are associated with atherosclerosis and cardiovascular disorders. It might also be associated with malignancy and plays a regulatory role in multiple myeloma, prostate, breast, bladder and gastric carcinoma. OPG plays a vital role in bone metabolism and is involved in inhibition of ovariectomy-associated bone loss in rats. |
Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline. |
Analysis Note【分析说明】 | The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 50 ng/ml recombinant human TRAIL. |
产品性质
Quality Level【质量水平】 | 200 |
biological source【生物来源】 | mouse |
recombinant【重组】 | expressed in NSO cells |
Assay【测定】 | >95% (SDS-PAGE) |
form【形式】 | lyophilized powder |
potency【效能】 | 25-50 ng/mL ED50 |
mol wt【分子量】 | 100 kDa by SDS-PAGE (reducing) calculated mol wt 70.9 kDa |
packaging【包装】 | pkg of 100 μg |
impurities【杂质】 | endotoxin, tested |
UniProt accession no.【UniProt登记号】 | O08712 |
storage temp.【储存温度】 | −20℃ |
SMILES string | CCCCCCCCCCC#CCCCCCC(O)=O |
InChI | 1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-10,13-17H2,1H3,(H,19,20) |
InChI key | XXUPLYBCNPLTIW-UHFFFAOYSA-N |
Gene Information | mouse ... Tnfrsf11b(18383) |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |