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Oxatomide
产品别名
60607-34-3
Oxatomide
1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H30N4O |
| Molecular weight | 426.55 |
| EC number【EC 号】 | 262-320-9 |
| MDL number | MFCD00211147 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278615 |
| NACRES | NA.77 |
| General description【一般描述】 | Oxatomide, a histamine H1-receptor antagonist, is bound at high levels to plasma proteins in human blood. |
| Biochem/physiol Actions【生化/生理作用】 | Oxatomide, found in several antihistamines, can suppress mast cell degranulation. It can be used as an alternative to individuals with allergic rhinitis who do not or poorly respond to more established antihistamines. Oxatomide exhibits both antihistamine and anti-inflammatory properties. It exhibits therapeutic effects against asthma and vulvar lichen sclerosus. Oxatomide is an anti-allergy compound. It suppresses platelet activating factor (PAF)-induced bronchoconstriction and inhibits leukotriene production. |
| Features and Benefits【特点和优势】 | This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥99% |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: soluble ethanol: soluble |
| originator【创始人】 | Johnson & Johnson |
| SMILES string | O=C1Nc2ccccc2N1CCCN3CCN(CC3)C(c4ccccc4)c5ccccc5 |
| InChI | 1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32) |
| InChI key | BAINIUMDFURPJM-UHFFFAOYSA-N |
| Gene Information | human ... DRD3(1814) |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
