Oxidized Nifedipine

C₁₇H₁₆N₂O₆

344.32

MFCD00153847

329827652

NA.77

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.
Oxidized Nifedipine may be used:

• to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC)
• as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes
• in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α)

Nifedipine is a dihydropyridine derivative and a calcium channel blocker. It is used in treating hypertension and angina pectoris. Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light. The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine.
CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. UC167.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

~95% (HPLC)

powder

yellow

100-105 ℃

2-8℃

COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O

1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3

UMQHJQGNGLQJPF-UHFFFAOYSA-N

5, 10 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

GHS05

Danger

H318

P280 - P305 + P351 + P338

Eye Dam. 1

13 - Non Combustible Solids

WGK 2

dust mask type N95 (US), Eyeshields, Gloves