P5091

C₁₂H₇Cl₂NO₃S₂

348.22

NA.77

P5091 has been used:

• as a ubiquitin specific peptidase 47 (USP47) inhibitor in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cellular viability of MCF-10A cells
• as a USP7 inhibitor to study the regulatory role for USP7 on inflammasome activation
• as USP7 inhibitor in drug susceptibility assays to study its effect on bone marrow−resident tumor cells (BMRTCs)/ circulating tumor cells (CTCs)

P5091 plays an important role in ovarian cancer, as it can prevent the growth of cells and can promote necrosis and apoptosis.
P5091 is a cell permeable, potent and specific inhibitor of deubiquitylating enzyme USP7 (Ubiquitin-Specific Protease-7) that induces HDM2 polyubiquitylation and accelerates degradation of HDM2. P5091 induces apoptosis in MM cells resistant to conventional and bortezomib therapies. P5091 inhibits tumor growth and prolongs survival in animal models of cancer.

100

≥98% (HPLC)

powder

light yellow to dark yellow

DMSO: 10 mg/mL, clear

2-8℃

5, 25 mg in glass bottle

GHS06

Danger

H301 - H413

P273 - P301 + P310 + P330

Acute Tox. 3 Oral - Aquatic Chronic 4

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK 3