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PD-166866
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3179589 | 5 MG | 1370 | |||
| 3179589 | 25 MG | 6640 |
产品别名
192705-79-6
PD-166866
1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H24N6O3 |
| Molecular weight | 396.44 |
| MDL number | MFCD12922514 |
| PubChem Substance ID【PubChem化学物质编号】 | 329823706 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4. |
| Features and Benefits【特点和优势】 | This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
| Other Notes【其他说明】 | This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
| Legal Information【法律信息】 | Sold for research purposes under agreement from Pfizer Inc. Pfizer is a registered trademark of Pfizer, Inc. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| manufacturer/tradename | Pfizer® |
| color【颜色】 | off-white to light tan |
| solubility【溶解性】 | DMSO: ≥10 mg/mL |
| originator【创始人】 | Pfizer |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | COc1cc(OC)cc(c1)-c2cc3cnc(N)nc3nc2NC(=O)NC(C)(C)C |
| InChI | 1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27) |
| InChI key | NHJSWORVNIOXIT-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
