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PD-407824
产品别名
622864-54-4
PD-407824
9-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H12N2O3 |
| Molecular weight | 328.32 |
| MDL number | MFCD09753286 |
| PubChem Substance ID【PubChem化学物质编号】 | 329823703 |
| NACRES | NA.77 |
| Application【应用】 | PD-407824 has been used as a wee-1 inhibitor to study its effects on Xenopus laevis embryos. It has also been used as a checkpoint-1 (Chk-1) inhibitor to study its effects on the sensitivity of head and neck squamous carcinoma cells to gemcitabine. |
| Biochem/physiol Actions【生化/生理作用】 | PD-407824 is a Wee1/Chk1 inhibitor. |
| Other Notes【其他说明】 | This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
| Legal Information【法律信息】 | Sold for research purposes under agreement from Pfizer Inc. Pfizer is a registered trademark of Pfizer, Inc. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Pfizer® |
| color【颜色】 | yellow to orange |
| solubility【溶解性】 | DMSO: >10 mg/mL |
| originator【创始人】 | Pfizer |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Oc1ccc2[nH]c3cc(-c4ccccc4)c5C(=O)NC(=O)c5c3c2c1 |
| InChI | 1S/C20H12N2O3/c23-11-6-7-14-13(8-11)16-15(21-14)9-12(10-4-2-1-3-5-10)17-18(16)20(25)22-19(17)24/h1-9,21,23H,(H,22,24,25) |
| InChI key | IAUZTOZLTFSMIE-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P261 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
