五氟利多

C₂₈H₂₇ClF₅NO

523.97

248-074-5

MFCD00866714

329820171

NA.77

Penfluridol has been used as an antipsychotic agent:

• to study its antimetastatic effect on triple-negative breast cancer cells
• to study its effects on the growth of glioblastoma cell lines,
• to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)

Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis. It also exhibits anticancer activity.
T-type Ca²⁺ channel blocker; antipsychotic

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

100

≥97% (HPLC)

powder

white

DMSO: >20 mg/mL
H₂O: insoluble

Johnson & Johnson

2-8℃

OC1(CCN(CCCC(c2ccc(F)cc2)c3ccc(F)cc3)CC1)c4ccc(Cl)c(c4)C(F)(F)F

1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

MDLAAYDRRZXJIF-UHFFFAOYSA-N

50 mg in glass bottle

GHS06

Danger

H301

P301 + P310

Acute Tox. 3 Oral

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK 3

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges