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PHA 767491 hydrochloride
产品别名
845538-12-7
PHA 767491 hydrochloride
1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride
PHA-00767491 hydrochloride
2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H11N3O · xHCl |
| Molecular weight | 213.24 (free base basis) |
| MDL number | MFCD11519962 |
| PubChem Substance ID【PubChem化学物质编号】 | 329823752 |
| NACRES | NA.77 |
| Application【应用】 | PHA 767491 hydrochloride has been used to study its effect on estrogen-induced DNA damage. It has also been used in western blot analysis and to study the S9.6 nuclear signal in HeLa cells. |
| Biochem/physiol Actions【生化/生理作用】 | PHA 767491 serves as a potential anticancer drug. It shows an ameliorating effect against acute myeloid leukemia, colon and breast cancer models. PHA 767491 possesses anti proliferating and apoptotic effect. PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. |
| Other Notes【其他说明】 | This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
| Legal Information【法律信息】 | Sold for research purposes under agreement from Pfizer Inc. Pfizer is a registered trademark of Pfizer, Inc. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Pfizer® |
| color【颜色】 | off-white to yellow |
| solubility【溶解性】 | H2O: >25 mg/mL |
| originator【创始人】 | Pfizer |
| SMILES string | Cl.O=C1NCCc2[nH]c(cc12)-c3ccncc3 |
| InChI | 1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H |
| InChI key | IMVNFURYBZMFDZ-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
