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Profilin from Toxoplasma gondii
| 产品编号： | 3208219 |
| 规格： | recombinant, expressed in E. coli, >95% (SDS-PAGE) |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Profilin from Toxoplasma gondii
Inflammatory profilin
T Cell Membrane Protein 1
基本信息
| NACRES | NA.32 |
| Biochem/physiol Actions【生化/生理作用】 | Profilin is a protozoan parasite protein. It activates toll-like receptor 11 (TLR11), which is an intracellular receptor localized on the endoplasmic reticulum (ER). TLR11 acts as an innate immune sensor for T. gondii profilin (TgPRF).The 12 membrane-spanning ER-resident protein UNC93B1 directly binds TLR11 and control the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12 also has an ability to interact with (TgPRF). TLR12 is adequate for recognizing profilin in plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both needed in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice fail to resist T. gondii infection. |
| Physical form【外形】 | Lyophilized from PBS. |
| Reconstitution【重悬】 | Reconstitute with 100 μL deionized water. |
| Other Notes【其他说明】 | Recombinant profilin (Toxoplasma gondii) (aa 1-163). |
产品性质
| biological source【生物来源】 | Toxoplasma gondii |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | >95% (SDS-PAGE) |
| form【形式】 | lyophilized |
| mol wt【分子量】 | ~20 kDa by SDS-PAGE |
| packaging【包装】 | pkg of 10 μg |
| storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
| impurities【杂质】 | <0.01 EU/μg endotoxin, tested |
| color【颜色】 | white |
| UniProt accession no.【UniProt登记号】 | Q58NA1 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | Toxoplasma gondii ... PRF(7900190) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
