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R(+)-维拉帕米 单盐酸盐 水合物
R(+)-Verapamil monohydrochloride hydrate
| 产品编号： | 3213368 |
| 规格： | ≥98% (HPLC), powder |
| CAS NO： | 38176-02-2 |
| 包装规格： | 5 MG，25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
38176-02-2
R(+)-维拉帕米 单盐酸盐 水合物
R(+)-Verapamil monohydrochloride hydrate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H38N2O4 · HCl · xH2O |
| Molecular weight | 491.06 (anhydrous basis) |
| EC number【EC 号】 | 205-800-5 |
| MDL number | MFCD11046028 |
| PubChem Substance ID【PubChem化学物质编号】 | 24900706 |
| NACRES | NA.77 |
| Application【应用】 | R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity. |
| Biochem/physiol Actions【生化/生理作用】 | Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature. Inhibitor of P-glycoprotein; less active enantiomer of (±)-verapamil. |
| Caution【注意】 | hygroscopic |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| optical activity【旋光性】 | [α]22/D +9.6°, c = 0.5 in ethanol(lit.) |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white |
| solubility【溶解性】 | H2O: >30 mg/mL ethanol: soluble |
| SMILES string | O.Cl.COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC |
| InChI | 1S/C27H38N2O4.ClH.H2O/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H;1H2/t27-;;/m1../s1 |
| InChI key | ICKXRKHJKXMFLR-KFSCGDPASA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 + H311 + H331 |
| Precautionary Statements | P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
