Rabbit anti-Claspin Antibody, Affinity Purified

NA.41

The epitope recognized by PLA0075 maps to a region between residues 450 and 500 of human Claspin using the numbering given in entry AAG24515.1 (GeneID 63967).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Claspin is a checkpoint protein that interacts with and regulates checkpoint kinase 1 (Chk1) in response to replication stress. The interaction between claspin and Chk1 has been demonstrated to be required for ATR-dependent Chk1 activation. The interaction involves the phosphorylation of claspin that may be accomplished by Chk1 kinase activity. Claspin has been found to localize to chromatin in both the presence and absence of damaged DNA and to associate with PCNA, as an essential component of the DNA replication machinery. This association with the replication machinery may indicate a role for claspin in linking replication to DNA damage signaling and Chk1 activation.

rabbit

100

affinity purified immunoglobulin

primary antibodies

Powered by Bethyl Laboratories, Inc.

human

immunohistochemistry: 1:500-1:2,000
immunoprecipitation (IP): 1- 5 μg/mg
western blot: 1:500- 1:2,500

AAG24515.1

wet ice

2-8℃

rabbit ... Claspin(63967)

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12 - Non Combustible Liquids

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