Rabbit anti-Sin1 Antibody, Affinity Purified

NA.41

The epitope recognized by PLA0157 maps to a region between residue 470 and the C-terminus (residue 522) of human stress-activated map kinase interacting protein 1 using the numbering given in entry NP_001006618.1 (GeneID 79109).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Stress-activated map kinase-interacting protein 1 (Sin1) is highly similar to the yeast stress- activated protein kinase SIN1. Sin1 is an essential mTORC2 subunit that is required to act as the PDK2 that phosphorylates Akt/PKB at Ser 473. Sin1 has been implicated as a scaffolding protein. Sin1 is required for rictor binding in the mTORC2 complex. Sin1 has also been shown to be important to the SAPK (stress-activated kinase) signaling pathway and in the nucleus may act as a scaffold between ATF-2 and p38 to facilitate p38-induced phosphorylation of ATF-2. Sin1 is also found to form a complex with c-Jun N-terminal kinase (JNK) and may similarly function as a scaffolding protein in JNK signaling.

rabbit

100

affinity purified immunoglobulin

primary antibodies

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human

immunohistochemistry: 1:1,000- 1:5,000
immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000- 1:10,000

NP_001006618.1

wet ice

2-8℃

rabbit ... Sin1(79109)

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