Rabbit anti-SMN1 Antibody, Affinity Purified

NA.41

The epitope recognized by PLA0219 maps to a region between residue 244 and 294 of human survival of motor neuron 1 using the numbering given in entry NP_000335.1 (GeneID 6606).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Survival motor neuron protein (SMN1) has been identified as the gene that is defective in spinal muscular atrophy (SMA), a neurodegenerative autosomal recessive disease characterized by paralysis and muscular atrophy which results from the loss of motor neurons in the spinal cord. There are two closely related SMN genes that do not appear to be functionally redundant. SMN1 represents the telomeric copy while SMN2 represents the centromeric copy. In the cell, SMN1 is part of a large complex of proteins involved in snRNP biogenesis. The functional role of SMN1 is proposed to play a role in messenger and ribosomal RNA transcription and processing.

rabbit

100

affinity purified immunoglobulin

primary antibodies

Powered by Bethyl Laboratories, Inc.

human

immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000- 1:10,000

NP_000335.1

wet ice

2-8℃

rabbit ... SMN1(6606)

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12 - Non Combustible Liquids

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