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Ro 15-4513
产品别名
91917-65-6
Ro 15-4513
Ethyl 8-azido-6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Ro15-4513
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H14N6O3 |
| Molecular weight | 326.31 |
| MDL number | MFCD00078598 |
| PubChem Substance ID【PubChem化学物质编号】 | 24899343 |
| Application【应用】 | Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies. |
| Biochem/physiol Actions【生化/生理作用】 | Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine. |
| Features and Benefits【特点和优势】 | This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| form【形式】 | solid |
| color【颜色】 | tan |
| solubility【溶解性】 | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL H2O: insoluble methanol: soluble |
| originator【创始人】 | Roche |
| SMILES string | CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(ccc-23)N=[N+]=[N-] |
| InChI | 1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 |
| InChI key | CFSOJZTUTOQNIA-UHFFFAOYSA-N |
| Gene Information | human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559) rat ... Gabrg1(140674) |
| packaging【包装】 | 25, 100 mg in poly bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
