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Ro 41-0960
产品别名
125628-97-9
Ro 41-0960
2′-Fluoro-3,4-dihydroxy-5-nitrobenzophenone
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C13H8FNO5 |
| Molecular weight | 277.20 |
| MDL number | MFCD00078597 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278193 |
| NACRES | NA.77 |
| Application【应用】 | Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism. |
| Biochem/physiol Actions【生化/生理作用】 | Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids. |
| Features and Benefits【特点和优势】 | This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
| Caution【注意】 | Store tightly sealed at 4 ℃, protected from exposure to light. |
产品性质
| Quality Level【质量水平】 | 100 |
| form【形式】 | solid |
| storage condition【储存条件】 | protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | H2O: slightly soluble <0.7 mg/mL 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL ethanol: soluble |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F |
| InChI | 1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H |
| InChI key | RQPAUNZYTYHKHA-UHFFFAOYSA-N |
| Gene Information | human ... COMT(1312) |
| packaging【包装】 | 25, 100 mg in poly bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
