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S32826 disodium salt hydrate
产品别名
1096770-84-1
S32826 disodium salt hydrate
[4-(Tetradecanoylamino)benzyl]phosphonic acid disodium salt hydrate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H34NNa2O4P · xH2O |
| Molecular weight | 441.45 (anhydrous basis) |
| MDL number | MFCD12912442 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824492 |
| NACRES | NA.25 |
| Application【应用】 | S32826, a potent inhibitor of autotaxin (ATX), may be used to identify and characterize the lyso-phospholipase D (lysoPLD, ATX) involved in bioactive lyso-phosphatidic acid (LPA) formation. S32826 may be used to help determine the role of ATX in malignant cell processes such as tumorigenesis, invasion, and metastases; cardia bifida and atherosclerosis. |
| Biochem/physiol Actions【生化/生理作用】 | S32826 is a potent inhibitor of autotaxin. Autotaxin is a newly discovered lyso-phospholipase D (lysoPLD). Autotaxin and lyso-phosphatidic acid (LPA) have been associated with early cancer progression and motility of cancer cells as well as with metastasis. Because of localization (adipose tissue), the enzyme might play an important role in diabetes and obesity. Autotaxin might be the only source of LPA. S32826 is the strongest inhibitor of autotaxin reported. The compound shows activity in cellular or ex vivo models. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white |
| solubility【溶解性】 | H2O: ≥10 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | [Na+].[Na+].CCCCCCCCCCCCCC(=O)Nc1ccc(CP([O-])([O-])=O)cc1 |
| InChI | 1S/C21H36NO4P.2Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-21(23)22-20-16-14-19(15-17-20)18-27(24,25)26;;/h14-17H,2-13,18H2,1H3,(H,22,23)(H2,24,25,26);;/q;2*+1/p-2 |
| InChI key | DGRFALMFDGBLCP-UHFFFAOYSA-L |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
