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Salermide
产品别名
1105698-15-4
Salermide
N-{3-[(2-Hydroxy-naphthalen-1-ylmethylene)-amino]-phenyl}-2-phenyl-propionamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H22N2O2 |
| Molecular weight | 394.47 |
| MDL number | MFCD12912446 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824611 |
| NACRES | NA.77 |
| Application【应用】 | Salermide was used to treat human pulmonary artery smooth muscle cells to study the effect of SIRT1 inhibition on expression of atrogin by qPCR.1 |
| Biochem/physiol Actions【生化/生理作用】 | Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor (III histone deacetylases inhibitor). In vitro Salermide has a stronger inhibitory effect on Sirt2 than on Sirt1. Salermide induces massive apoptosis in tumor cells. The activity was ascribed to effect of Salermide to the reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1. Salermide is a stronger Sirtuin inhibitor than sirtinol (Cat. No.S7942). |
| Features and Benefits【特点和优势】 | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: >10 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC(C(=O)Nc1cccc(c1)\N=C\c2c(O)ccc3ccccc23)c4ccccc4 |
| InChI | 1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)/b27-17+ |
| InChI key | HQSSEGBEYORUBY-WPWMEQJKSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
