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Sitamaquine tosylate
产品别名
1019640-33-5
Sitamaquine tosylate
N-[6-(Diethylamino)hexyl]-6-methoxy-4-methylquinolin-8-amine tosylate
6-Methoxy-8-(6-diethylaminohexylamine)-4-methylquinoline tosylate
WR-6026
N1,N1-Diethyl-N6-(6-methoxy-4-methyl-8-quinolinyl)-1,6-hexanediamine tosylate
NSC 2452
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H33N3O · C7H8O3S |
| Molecular weight | 515.71 |
| MDL number | MFCD17392572 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825952 |
| Biochem/physiol Actions【生化/生理作用】 | Sitamaquine is also known as WR-6026. It is used in the treatment of visceral leishmaniasis. Sitamaquine is an orally active 8-aminoquinoline analog that exhibit antiplasmodial and antileishmanial activities. Sitamaquine accumulates in Leishmania parasites. Sitamaquine potently inhibits respiratory chain complex II (succinate dehydrogenase), which leads to an apoptosis-like death of Leishmania parasites. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 15 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC1=C(C=C(OC)C=C2NCCCCCCN(CC)CC)C2=NC=C1.CC3=CC=C(S(=O)(O)=O)C=C3 |
| InChI | 1S/C21H33N3O.C7H8O3S/c1-5-24(6-2)14-10-8-7-9-12-22-20-16-18(25-4)15-19-17(3)11-13-23-21(19)20;1-6-2-4-7(5-3-6)11(8,9)10/h11,13,15-16,22H,5-10,12,14H2,1-4H3;2-5H,1H3,(H,8,9,10) |
| InChI key | LOBPWLFCZDGYKW-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
