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SKF-83959 hydrobromide
产品别名
80751-85-5
SKF-83959 hydrobromide
6-Chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H20NClO2 · HBr |
| Molecular weight | 398.72 |
| MDL number | MFCD03792727 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278699 |
| NACRES | NA.77 |
| Application【应用】 | SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα in mice. |
| Biochem/physiol Actions【生化/生理作用】 | SKF-83959 is an atypical agonist of D1 dopamine receptor and an allosteric modulator of σ-1 receptor on in brain and liver tissues. It has neuroprotective and anti-parkinsonian effects through selective activation of phosphoinositol-linked D1 receptor and promotes migration of cultures astrocytes by ERK1/2 activation. In in vitro studies SKF-83959 exhibits antagonist activity against dopamine D1 receptors coupled to adenylyl cyclase. D1 dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: >20 mg/mL H2O: insoluble |
| SMILES string | Br[H].CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c3cccc(C)c3 |
| InChI | 1S/C18H20ClNO2.BrH/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19;/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3;1H |
| InChI key | FHYWNBUFNGHNCP-UHFFFAOYSA-N |
| Gene Information | human ... DRD1(1812) |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
