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SM-19712 hydrate
产品别名
194542-56-8
SM-19712 hydrate
4-Chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl]benzenesulfonamide sodium salt hydrate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H13ClN5NaO3S · xH2O |
| Molecular weight | 437.84 (anhydrous basis) |
| MDL number | MFCD06798351 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824532 |
| NACRES | NA.77 |
| Application【应用】 | SM-19712 hydrate was used in studies to determine the effectiveness of ECE inhibition as a treatment option for Alzheimer′s disease. |
| Biochem/physiol Actions【生化/生理作用】 | SM-19712 a sulfonylureid-pyrazole derivative is a potent and selective inhibitor of endothelin converting enzyme (ECE). It attenuates the effects of ischemic acute renal failure and reduces the inflammation, tissue injury and vasoconstriction induced by dextran sodium sulfate in mouse colon. Nonpeptide, potent and selective endothelin converting enzyme inhibitor. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | off-white to light brown |
| solubility【溶解性】 | DMSO: ≥20 mg/mL H2O: ≥20 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | ClC1=CC=C(S(N(C(NC2=C(C#N)C(C)=NN2C3=CC=CC=C3)=O)[Na])(=O)=O)C=C1 |
| InChI | 1S/C12H10ClN5O3S.Na.H2O/c1-7-10(6-14)11(17-16-7)15-12(19)18-22(20,21)9-4-2-8(13)3-5-9;;/h2-5H,1H3,(H3,15,16,17,18,19);;1H2/q;+1;/p-1 |
| InChI key | HLHPDQXMLDUDQV-UHFFFAOYSA-M |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
