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SMPT (4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene)
产品别名
112241-19-7
SMPT (4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene)
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H20N2O2S2 |
| Molecular weight | 360.49 |
| MDL number | MFCD00083161 |
| PubChem Substance ID【PubChem化学物质编号】 | 329768810 |
| NACRES | NA.22 |
| General description【一般描述】 | SMPT is a heterobifunctional sulfhydryl- and amine-reactive cross-linker. SMPT is used often for conjugating a toxin molecule to a monoclonal antibody directed against a cell-surface antigen. These immunotoxins produced with SMPT are highly potent as the cleavable disulfide imparts increased cytotoxicity compared to conjugates without a cleavable bond, such as those produced with SPDP. Also, next to the pyridine-2-thione in the spacer arm are a benzene ring and a methyl group adjacent to a carbon that hinders the disulfide bond, allowing exceptional conjugate stability in vivo. SMPT has the added benefit of being more stable to hydrolysis in aqueous solutions than other NHS cross-linkers. |
| Features and Benefits【特点和优势】 |
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| Caution【注意】 | This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥90% |
| form【形式】 | powder |
| mol wt【分子量】 | 388.46 |
| reaction suitability | reagent type: cross-linking reagent |
| storage condition【储存条件】 | desiccated |
| solubility【溶解性】 | DMSO or DMF: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(ON1C(CCC1=O)=O)C2=CC=C(C(SSC3=CC=CC=N3)C)C=C2 |
| InChI | 1S/C18H16N2O4S2/c1-12(25-26-15-4-2-3-11-19-15)13-5-7-14(8-6-13)18(23)24-20-16(21)9-10-17(20)22/h2-8,11-12H,9-10H2,1H3 |
| InChI key | GKSPIZSKQWTXQG-UHFFFAOYSA-N |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
