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SR 12813
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3242746 | 1 MG | 665 | |||
| 3242746 | 5 MG | 2010 |
产品别名
126411-39-0
SR 12813
Tetraethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H42O7P2 |
| Molecular weight | 504.53 |
| MDL number | MFCD00888473 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824541 |
| NACRES | NA.77 |
| Application【应用】 | SR-12813 was used as control in pregnane X receptor (PXR) binding assay performed in HepG2 liver carcinoma cells and PXR-activation assay mediated by dehydroepiandrosterone in human hepatocytes. |
| Biochem/physiol Actions【生化/生理作用】 | SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase. SR 12813 is a pregnane X receptor (PXR, NR 112) agonist; cholesterol lowering drug; HMGCoA reductase inhibitor. |
| Features and Benefits【特点和优势】 | This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
产品性质
| biological source【生物来源】 | synthetic (organic) |
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% |
| form【形式】 | solid |
| solubility【溶解性】 | DMSO: ≥10 mg/mL H2O: insoluble |
| originator【创始人】 | GlaxoSmithKline |
| SMILES string | CCOP(=O)(OCC)C(=C/c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)\P(=O)(OCC)OCC |
| InChI | 1S/C24H42O7P2/c1-11-28-32(26,29-12-2)21(33(27,30-13-3)31-14-4)17-18-15-19(23(5,6)7)22(25)20(16-18)24(8,9)10/h15-17,25H,11-14H2,1-10H3 |
| InChI key | YQLJDECYQDRSBI-UHFFFAOYSA-N |
| packaging【包装】 | 1, 5 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
