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STF-118804
产品别名
894187-61-2
STF-118804
4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)-benzamide
STF 118804
4-(5-Methyl-4-(tosylmethyl)oxazol-2-yl)-N-(pyridin-3-ylmethyl)benzamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C25H23N3O4S |
| Molecular weight | 461.53 |
| MDL number | MFCD14918065 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825804 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | STF-118804 is a highly specific and potent NAMPT (nicotinamide phosphoribosyl transferase) inhibitor that reduces the viability of most B-ALL cell lines. STF 118804 induces leukemia cell apoptosis including leukemia initiating (stem) cells. STF 118804 improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia. STF-118804 displays pancreatic ductal adenocarcinoma (PDAC) growth reducing potential in combination with chemotherapeutic drugs. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(C1=CC=C(C2=NC(CS(=O)(C3=CC=C(C)C=C3)=O)=C(C)O2)C=C1)NCC4=CN=CC=C4 |
| InChI | 1S/C25H23N3O4S/c1-17-5-11-22(12-6-17)33(30,31)16-23-18(2)32-25(28-23)21-9-7-20(8-10-21)24(29)27-15-19-4-3-13-26-14-19/h3-14H,15-16H2,1-2H3,(H,27,29) |
| InChI key | DLFCEZOMHBPDGI-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
