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Strontium Ranelate
产品编号:3245303
规格:≥98% (HPLC)
CAS NO:135459-87-9
包装规格:10 MG,50 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
324530310 MG658
324530350 MG2550
产品别名

135459-87-9

雷尼酸锶

Strontium Ranelate

2-[N,N-Di(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylic acid strontium salt

Distrontium renelate

5-[Bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid, strontium salt

Ranelic Acid Strontium Salt

基本信息
Empirical Formula【经验(实验)分子式】
C12H6N2O8SSr2
Molecular weight
513.49
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
Strontium ranelate is a dual action bone agent (DABA). It inhibits bone resorption and stimulates bone formation, inhibiting osteoclast differentiation while activating gene expression in osteoblasts. While its exact mechanism of action is unknown, one hypothesis is that both anabolic and anti-catabolic activities may involve antagonizing nuclear factor-KB (NF-KB) activation in bone cells. Strontium ranelate has been shown to inhibit the receptor activator of NF-KB ligand (RANKL)-induced nuclear translocation of NF-KB and activator protein-1. Strontium ranelate has been used clinically for the treatment of osteoporosis and a recent multinational study indicates the drug can also be used to treat osteoarthritis.
Features and Benefits【特点和优势】
This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
color【颜色】
white to beige
solubility【溶解性】
H2O: 1 mg/mL, clear (warmed)
storage temp.【储存温度】
−20℃
packaging【包装】
10, 50 mg in glass bottle
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H302 + H312 + H332
Precautionary Statements
P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
Hazard Classifications【危险分类】
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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