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STX64
产品别名
288628-05-7
STX64
BN 83495
667 Coumate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H15NO5S |
| Molecular weight | 309.34 |
| MDL number | MFCD12912443 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824496 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | STX64 is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC50 = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity. |
| Features and Benefits【特点和优势】 | This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: >20 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | NS(=O)(=O)Oc1ccc2C3=C(CCCCC3)C(=O)Oc2c1 |
| InChI | 1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18) |
| InChI key | DSLPMJSGSBLWRE-UHFFFAOYSA-N |
| Gene Information | human ... STS(412) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
