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产品别名
5812-07-7
SU 4312
3-(4-Dimethylaminobenzylidenyl)-2-indolinone
3-[[(4-Dimethyl-amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H16N2O |
| Molecular weight | 264.32 |
| MDL number | MFCD00118147 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278803 |
| Application【应用】 | SU 4312 was used to study angiogenesis during development of zebrafish embryos.2 |
| Biochem/physiol Actions【生化/生理作用】 | SU 4312 inhibits the neuronal NOS and exhibits neuroprotection against NO-mediated neurotoxicity. It might be effective in treatment of neurodegenerative disorders.1 SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. |
| Features and Benefits【特点和优势】 | This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
| Other Notes【其他说明】 | This product is a mixture of the cis- and trans- isomers. The ratio is about 55:45 based on HPLC. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | orange |
| solubility【溶解性】 | DMSO: >10 mg/mL H2O: insoluble |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CN(C)c1ccc(cc1)\C=C2\C(=O)Nc3ccccc23 |
| InChI | 1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11+ |
| InChI key | UAKWLVYMKBWHMX-RVDMUPIBSA-N |
| Gene Information | human ... FLT1(2321) |
| packaging【包装】 | 5 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
